Cambridge Healthtech Institute’s Second Annual  

Epigenomics in Disease  

Above the Genome - Underlying Disease

February 16-18, 2015 | Moscone North Convention Center | San Francisco, CA
Part of the 22nd Annual Molecular Medicine Tri-Conference


It is now universally recognized that dysregulation of the regulatory layers above the genome—namely the epigenome consisting of DNA methylation, histone marks and non-coding RNA—is directly involved in producing aberrant gene expression leading to disease. With advances in sequencing technologies, drivers and mechanisms of disease initiation are being unraveled, and a more holistic view of the interplay between the genome and a very active epigenome is taking shape. Importantly, these findings form inextricable causal links between our underlying genome, the regulatory epigenome, and the functional (disease) consequence stemming from both.

The Epigenomics in Disease meeting is designed to highlight the interplay between genome-epigenome-disease, while exploring the profound opportunities of applying epigenomic analysis for diagnostics and personalized treatment.

keynote session: Advances in Interrogating (Epi)Genomes

Regulatory Genomics and Epigenomics of Complex Disease

Manolis Kellis, Ph.D., Professor, Computer Science, MIT; Director, Computational Biology Group, Computer Science and Artificial Intelligence Lab (CSAIL), Broad Institute of MIT and Harvard

Shaping the Blood: Lessons from Chromatin and Single Cell RNA Dynamics

Ido Amit, Ph.D., Principal Investigator, Laboratory for Immuno-Genomics, Weizmann Institute of Science



Co-Dependency of the Genome and Epigenome during Tumor Evolution

Joseph Costello, Ph.D., Professor in Residence, Department of Neurological Surgery; Director, Epigenetics Division, Cell Cycling and Signaling Program, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco

Epigenome-Wide Landscape of Melanoma Progression to Brain Metastasis

David Hoon, Ph.D., Chief, Scientific Intelligence, Director, Molecular Oncology, John Wayne Cancer Institute

Epigenetic Addition: A Tale of Paediatric High-Grade Brain Tumors

Nada Jabado, M.D., Ph.D., Associate Professor, Pediatrics; Associate Member, Department of Human Genetics, Oncology and Experimental Medicine, McGill University

Genetic-Epigenetic Interactions in Cis and Trans: Relevance to the Human Brain and Immune System

Benjamin Tycko, M.D., Ph.D., Professor, Pathology and Cell Biology, Institute for Cancer Genetics &Taub Institute for Research on Alzheimer’s Disease and the Aging Brain, Columbia University

Chromatin Dynamics and Long-Range Regulatory Control

Featured Presentation: Epigenome Remodelling and DNA Replication Timing: What are the Implications in Cancer?

Susan Clark Ph.D., Professor & Director, Epigenomics Centre, The Kinghorn Cancer Centre, Garvan Institute of Medical Research

BAF Complexes in Human Malignancy

Cigall Kadoch, Ph.D., Principal Investigator, Pediatric Oncology, Dana-Farber Cancer Institute; Assistant Professor, Department of Pediatrics, Harvard Medical School

ePIGENETIC Mechanisms Underpinning Disease

Crosstalk between DNA Methylation and Histone Methylation in Mammalian Development and Disease

Taiping Chen, Ph.D., Associate Professor, Department of Molecular Carcinogenesis, Division of Basic Science Research, The University of Texas MD Anderson Cancer Center

Linking Histone Recognition to the Epigenetic Inheritance of DNA Methylation

Brian Strahl, Ph.D., Associate Professor & Director, Graduate Studies of Biochemistry & Biophysics, University of North Carolina School of Medicine

DNA Methylation Biomarkers in Cancer

DNA Methylation as Cancer Biomarkers in Clinical Development

David Shames, Ph.D., Senior Scientist, Genentech

Defining the Epigenetic Landscape during Normal and Malignant Hematopoiesis

Lucy A. Godley, M.D., Ph.D., Associate Professor, Department of Medicine, Section of Hematology/Oncology, Cancer Research Center, The University of Chicago

DNA Methylation Alterations in Lung Adenocarcinoma

Ite A. Laird-Offringa, Ph.D., Director, Biomedical and Biological Sciences; Associate Professor, Surgery, Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California

Epigenomic Technologies & Data Analysis

3D Genome Conformation and Gene Transcription Regulation in Human Diseases

Yijun Ruan, Ph.D., Professor and Director, Genome Sciences, Jackson Laboratory Genomic Medicine

Whole-Genome Epigenomic Analysis of Cancer

Benjamin P. Berman, Ph.D., Assistant Professor, Division of Bioinformatics, Department of Preventive Medicine; Member, USC Epigenome Center, University of Southern California

Advances in Computational Epigenomics

Héctor Corrada Bravo, Ph.D., Assistant Professor, Department of Computer Science, UM Institute for Advanced Computer Studies & Center for Bioinformatics and Computational Biology, University of Maryland



For more details on the conference, please contact:
Kip Harry
Conference Director
Cambridge Healthtech Institute
T: (+1) 781-972-5454

For partnering and sponsorship information, please contact:
Jon Stroup (Companies A-K)
Manager, Business Development
Cambridge Healthtech Institute
T: (+1) 781-972-5483

Joseph Vacca (Companies L-Z) 
Manager, Business Development
Cambridge Healthtech Institute
T: (+1) 781.972.5431



  2015 Plenary Sessions 

2015 MMTC Prelim Agenda 

Premier Sponsors:


Jackson Laboratory - small logo 

Leica Biosystems 




Thomson Reuters-Large 

Local Partners:




City of SSF