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Adopting R&D Informatics Systems - Data Management, Integration & Knowledge Management

Wednesday, February 3

7:00 AM Registration and Morning Coffee

Plenary Keynote Session

8:10 When Drug Research is Personal

John F. Crowley, Founder, Novazyme Pharmaceuticals, Inc.

Mr. Crowley’s emotion-packed presentation will focus on his personal struggle to find a cure for Pompe disease, a rare and fatal illness that is caused by a defective or missing enzyme. Pompe disease affects fewer than 10,000 people world-wide, including Mr. Crowley’s two small children. Mr. Crowley, a Harvard educated businessman, created and built a pharmaceutical company devoted expressly to finding a cure for the disease. He will detail his journey through the labyrinth of scientific and business fronts, which lead up to a first-round clinical trial.

8:55 Technology, Aging, and the Brain

Gary W. Small, M.D., Parlow-Solomon Professor on Aging, Professor of Psychiatry & Biobehavioral Sciences, Director, UCLA Center on Aging, Director, Memory & Aging Research Center, Director, Geriatric Psychiatry Division, Semel Institute for Neuroscience & Human Behavior, David Geffen School of Medicine at UCLA

New neuroimaging and other technologies are teaching us about how the brain ages and what we can do about it. Although memory declines as we age, medical and nonpharmacological strategies may protect brain health and improve memory performance. At the same time, innovation in digital technology is not only changing the way we live and communicate, it appears to be altering how our brains function. As a consequence of this high-tech stimulation, we are witnessing the beginning of a new form of the generation gap – a brain gap dividing younger digital natives, immersed in the technology early in life, from older digital immigrants, who adapt to the new technology more reluctantly. This lecture will describe this current pivotal point in brain evolution and how we can harness the new technology and lifestyle choices to improve memory and brain function so we can live better and longer. 

9:40 Grand Opening Refreshment Break in the Exhibit Hall

 

EXECUTIVE STRATEGIES–INTEGRATED R&D INFORMATICS 

11:00 Chairperson’s Remarks

David M. Sedlock, Ph.D., Senior Director, Research & Development Systems, Millennium, The Takeda Oncology Company

11:10 Enterprise Scientific Workflow Environment Drives Innovation

Daniel J. Chin, Ph.D., Senior Principal Research Scientist, Roche Palo Alto

Most informatics investments increase the efficiency of drug discovery. The introduction of an enterprise-wide scientific workflow platform enables research informatics organizations to shift their efforts towards scientific innovation. Researchers apply scientific workflows for in silico experimentation and exploration, leading to scientific hypotheses and discoveries. Enterprise environments enable researchers to share and evolve their scientific workflows, further increasing research productivity. Examples of scientific workflows and the setting required to run scientific workflow platforms effectively in pharmaceutical research will be discussed.

11:40 The Pistoia Alliance, Inc.–A Construct for Precompetitive Collaboration

Chris Waller, Ph.D., Senior Director, Precompetitive Collaborations, Research, Development & Medical Informatics, Worldwide Technology, Pfizer, Inc.

The Pistoia Alliance has been established to provide the foundation of data standards, ontologies and associated web-services to enable the Pharmaceutical discovery workflow through common business terms, relationships and processes. Current progress, learnings and how companies, academics and others can participate in this approach will be described.

12:10 PM Recent Strategies with Cloud, Wikis, Ontologies and Open Source Data Standards

Giles M. Day, Senior Director, BBC Informatics, Pfizer, Inc.

The presentation will discuss strategies in use at Pfizer to drive Next Generation Sequencing and Biotherapeutics discovery using opensource and public platforms. The systems discussed capture, integrate, display and mine information to drive faster and more accurate decision making whilst reducing development times and support costs.

 

12:40 Luncheon Presentation I   Sponsored by  

*By attending Microsoft’s Luncheon presentation you are opting to receive further communications from Microsoft.
Personalized Medicine: The Missing Pieces

Jim Karkanias, Senior Director of Applied Research & Technology, Microsoft Health Solutions Group

Discoveries to make personalized medicine a reality depend on leveraging the "open universe" of life sciences data. To assist investigators with ad hoc questions, hypothesis generation, and validation, investigators must describe and verify systems about the life science universe. This session will introduce a strongly typed repository of linked data that makes it possible to conceive and deliver game-changing therapies.

1:10pm Luncheon Presentation II 
Empowering Scientists with Hypothesis-Driven Data Exploration

Jian Wang, Ph.D., CEO, BioFortis Inc.
A significant bottleneck on productivity in translational research is the inability for scientists to directly interrogate data by themselves. We present a novel solution & case study to demonstrate how, with the right tools, scientists can be more self-sufficient, efficient and productive, while enabling informatics specialists to focus more on higher value contributions instead of mundane ad hoc data manipulations.

Sponsored by

1:45 Dessert in the Exhibit Hall

2:15 Chairperson’s Remarks

David M. Sedlock, Ph.D., Senior Director, Research & Development Systems, Millennium, The Takeda Oncology Company

2:20 Integrated Informatics Systems for R&D

Vaibhav A. Narayan, Ph.D., Senior Director, Integrative Neurosciences & Biomarkers, Johnson & Johnson Pharmaceuical Research & Development

2:50 Executive Panel with Q&A

Are We Integrating the Right Data: Extending Beyond Laboratory Data to Decisions Impacting Project Success

Moderator: David M. Sedlock, Ph.D., Senior Director, Research & Development Systems, Millennium, The Takeda Oncology Company

  • Data Aggregation vs. Data Integration
  • Data Management vs. Knowledge Management
  • Integrating Data Management Systems across Multiple Sites
  • Effective Data Integration in Translational Medicine Research
  • Role of Open Source Technology in Systems Design
  • Is There a ‘Cloud’ in Your Future?
  • Barriers Sharing Research and Development Data
  • Process Management vs. Technology Considerations when Deploying New Systems

Panelists:

Giles M. Day, Senior Director, BBC Informatics, Pfizer, Inc.

Daniel J. Chin, Ph.D., Senior Principal Research Scientist, Roche Palo Alto

Susie Stephens, Director, Biomedical Informatics, Pharmaceutical Research & Development, Johnson & Johnson

Chris Waller, Ph.D., Senior Director, Precompetitive Collaborations, Research, Development & Medical Informatics, Worldwide Technology, Pfizer, Inc.

 

Sponsored by

3:50 Presentation  

Workflow based Enterprise Informatics

Frank Brown, Ph.D., Vice President & Chief Scientific Officer, Accelrys

Accelrys is producing a new generation of Enterprise Informatics systems for chemical, biological and image data registration and mining. The new generation features workflow driven application logic and business rules, clients that leverage the latest collaborative environments such as Microsoft SharePoint, and novel storage techniques to handle the complexity and diversity of today’s data types.

4:05 Sponsored Presentation (Sponsorship Opportunity Available)

4:20 Reception in the Exhibit Hall (Sponsorship Available)

5:20 BREAK-OUT DISCUSSIONS in the Exhibit Hall

E-Notebooks - The Power House of Integration?

Moderator: David M. Sedlock, Ph.D., Senior Director, Research & Development Systems, Millennium, The Takeda Oncology Company

  • Data Integration vs. System Integration
  • Value and Pitfalls of ELN Integration
  • Vendor Role (Impact of Customization)
  • Alternatives to ELN System Integration
  • ELN vs. LIMS vs. SDMS - How Do These Systems Achieve Maximum Value?

Ontologies and Semantic Web

Moderator: Susie Stephens, Director, Biomedical Informatics, Pharmaceutical Research & Development, Johnson & Johnson

  • Is There a Cloud in Your Future?
  • Aggregation of Key Information from Sources including Structural, Chemical and Biological Data along with Predictions of Activity

Open Source Data Standards

Moderator: Ajay Shah, Ph.D., MBA, PMP, Director, Research Informatics, Elan Pharmaceuticals, Inc.

  • Open source and public platforms
  • Role of Open Source Technology in Systems Design
  • Virtual Pharmaceutical collaborations

6:20 Close of Day

 

 

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2014 Premier Sponsors:

 Elsevier   

 

NanoString 

 

Quanterix 

 

RemedyMD 

 

Singulex 

 

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