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Thursday, February 4
8:25 AM Chairperson's Remarks
Thomas P. Hill, Principal, The Leverage Innovation Group; former Director, Learning and Knowledge Management, Genentech
8:30 SparkLab 360 - The Complete System for Managing your Lab Research
Roi Paz, Chief Executive Officer, SparkLix Bio-IT
Electronic lab notebooks (ELNs) and laboratory information management systems (LIMS) are essential tools in lab management. SparkLix – an Innovation Award recipient from the Association for Laboratory Automation – developed SparkLab 360, which integrates features from ELNs and LIMS in one user-friendly system. This presentation focuses on how SparkLab enables design, planning, execution and analysis of the entire research process.
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8:45 Knowledge Management
Speaker to be Announced
9:00 Knowledge for Strategic Advantage: Accelerating the R&D Cycle
Thomas P. Hill, Principal, The Leverage Innovation Group; former Director, Learning and Knowledge Management, Genentech
This presentation focuses on key elements of knowledge leveraged for strategic advantage in the Life Sciences industry, the key challenge of how to accelerate the R&D process by using collaborative informatics technologies and an examination of specific scientific business solution implementations for results. In addition, the key features of a robust collaborative scientific business solution will be identified.
9:30 ASAP-Emphasizing Multidimensional Drug Discovery
W. Patrick Walters, Ph.D., Senior Research Fellow & Group Head, Computational Drug Discovery Technologies, Vertex Pharmaceuticals, Inc.
ASAP is new software platform designed to help drug discovery teams make better decisions. ASAP provides an intuitive overview of the data that also allows scientists to easily "drill down" and examine the details of particular experiments. A combination of "filters" and heat maps allows teams to focus on aspects of the data while remaining aware of the "big picture".
10:00 Presentation
RISe Architecture – Architectural Aspects of an Integrated Research Informatics Platform
Ajay Shah, Ph.D., MBA, PMP, Director of Research Informatics, Elan Pharmaceuticals Inc.
Elan and Infosys are building a research data integration platform called RISe (Research Informatics System at élan). RISe enables registration of biological entities, their inventory, associated workflows, and integration with chemical data utilizing a workflow driven, multi-tiered, SOA based architecture built on the Microsoft.NET platform. To maximize extensibility in a research environment, the database combines Entity-Attribute-Value design for flexible definition of entities, efficiency-prioritized OLTP schema for inventory management, and a planned ETL interface to a semantic database.
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10:30 Poster Competition Refreshment Break & Raffles in the Exhibit Hall
11:30 Agile Software Development: Meeting the Rapidly Changing Needs in Drug Discovery
Man-Ling Lee, Ph.D., Senior Program Analyst, Discovery Chemistry, Small Molecule Drug Discovery, Genentech, Inc.
To support drug discovery project teams meeting their timelines, the CompChem/ChemInformatics Group at Genentech has established an agile approach to satisfy the changing needs. The basis are two flexible software platforms, AEREA (Aestel Scientific Information) and Pipeline Pilot (Accelrys). The presentation will discuss the implementation and impact of two applications: one for lead selection and one for DMPK data analysis.
12:00 PM Application of Translational Informatics in Tailored Therapeutics
Susie Stephens, Director, Biomedical Informatics, Pharmaceutical Research & Development, Johnson & Johnson
Researchers frequently face challenges in being able to answer translational questions of interest because data is held in disparate stores across discovery, development, and clinical practice. Linked Data has the potential to ease access to these data by making the connections between the data sets explicit in the form of data links. This presentation will describe how Linked Data has been used to integrate data sources and enable interesting insights.
12:30 Luncheon Presentation I
Managing Research Portfolios – Can IT help you?
Arvindh Balakrishnan, Vice President Life Sciences, Oracle
Joe Duncan, Chief Executive Officer, Teranode
Research departments work on hundreds of thousands of molecules, markers and targets. How can we simplify information gathering across your scientific community in order make consistent portfolio management decisions? This talk will focus on using Oracle technologies like semantic web; and how portfolios can be reflected in best in class portfolio management tools.
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1:00 Luncheon Presentation II
SOA-based IT Framework for Life Science Research
David A. Medina, Worldwide Life Science and Pharma Segment Executive, Hewlett-Packard Company
At present there are a wide variety of IT point solutions designed to meet various needs for data analysis and integration in life science research. However, there is no easy-to-deploy, standards-based IT framework, which can be used to integrate these various point solutions and disparate data sources. This presentation will present a collaborative platform for bioinformatics used in bioresearch based on a scalable, standards-based, easy-to-deploy, SOA-based architecture. This platform will facilitate the integration of intra-organizational research efforts and enable inter-organizational R&D collaboration. The platform will also enable pharma R&D organizations to effectively access disparate data sources and facilitate the cross-analysis of genomic, proteomic and clinical data. This research platform could enable the next generation of clinical research initiatives by providing a standards-based technology infrastructure allowing for much-needed commonality amongst research institutions that will afford easier collaboration between research partners as well as increase the effectiveness of their research efforts.
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1:45 Ice Cream Refreshment Break in the Exhibit Hall
2:15 Plenary Keynote Introduction
2:25 Chips, Clones and Living Beyond 100
Paul J.H. Schoemaker, Ph.D., M.B.A., Chairman and Chief Executive Officer, Decision Strategies International, Inc.; Research Director, Mack Center for Technological Innovation, The Wharton School; Adjunct Professor of Marketing, The Wharton School Adjunct Professor, Wharton School of Business
As information technologies and life sciences continue to converge, new business opportunities and challenges will arise for the field of diagnostics and beyond. This keynote reviews the deeper forces shaping the future of the biosciences, from social and economic to technological and political, including the stresses they will introduce for existing business models and healthcare. Not only will bioconvergence introduce new products, services and competitors, it may create entirely new industries on a scale larger than the computer revolution has to date. Several broad scenarios will be painted for the state of the biosciences in 2025 and the forces that might take us there, summarizing a multi-year strategy study conducted and supervised by the speaker at the Wharton school.
3:05 Refreshment Break in the Exhibit Hall
3:45 Chairperson's Remarks
Susie Stephens, Director, Biomedical Informatics, Pharmaceutical Research & Development, Johnson & Johnson
3:50 Data Integration-What's in it for Me?
Randal Chen, Ph.D., Director, Research Informatics, Amgen, South San Francisco
4:20 Semantic Web and Cloud Computing for Integrative Data Management and Analysis Infrastructure
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Jonas S. Almeida, Ph.D., Abell-Hanger Distinguished Professor, Bioinformatics and Computational Biology, University of Texas, M.D. Anderson Cancer Center
The systems nature of biological processes and the scalability of cloud computing created an irresistible trend towards distribution of both the data and the ecosystem of applications that analyze them. Accordingly, at M.D. Anderson Cancer Center we are exploring the use of semantic web to render distributed infrastructure manageable and its contents safely discoverable. An open-source prototype was developed, see s3db.org.
4:50 Collaborative Drug Discovery Humanitarian and Commercial Researcher Network Case Studies
Barry A. Bunin, Ph.D., Chief Executive Officer & President, Collaborative Drug Discovery (CDD), Inc.
Collaborative Drug Discovery (CDD) has created a community based platform that combines traditional drug discovery informatics with Web2.0 features to provide the best of both worlds. Recent efforts to selectively arrest TB in the dormant phase working with leading researchers and mining SAR data will be presented. A global community of leading TB researchers supported by leading foundations will be reviewed. Advances from communities working together on commercial drug discovery bringing together industry, foundations, and academia will also be emphasized.
5:05 Panel: Drug Discovery Collaborations in 2010
Moderator: Barry A. Bunin, Ph.D., Chief Executive Officer & President, Collaborative Drug Discovery (CDD), Inc.
- Biopharmaceutical - CRO collaborations
- Virtual Pharmaceutical collaborations
- PPP (academic-industry-foundation) collaborations
Panelists:
Vaibhav A. Narayan, Ph.D., Senior Director, Integrative Neurosciences & Biomarkers, Johnson & Johnson Pharmaceuical Research & Development
Uli Schmitz, Ph.D., Director, Structural Chemistry, Gilead
Adam Renslo, Ph.D., Associate Director, Chemistry, Adjunct Assistant Professor, Pharmaceutical Chemistry
5:50 Close of Day
Short Courses | Day 1 | Day 2 | Day 3 | Download Brochure