8:25 am Chairperson's Remarks
Robert Hollingsworth, Ph.D., Director, Cancer Biology, MedImmune, Inc.
8:30 Targeting Telomeres and Telomerase in Cancer Stem Cells
Calin O. Marian, MS.c., Ph.D., Assistant Professor, Department of Urology, University of Texas Southwestern Medical Center
Evidence has suggested that the capability for tumor recurrence and metastasis resides in cancer stem cells. Current investigation into the role of telomeres and telomerase in cancer stem cells (CSCs) has lead to viable approaches towards targeting telomerase in CSCs.
9:00 Imetelstat as an Inhibitor of Cancer Stem Cells
Martha Blaney, Pharm.D., Medical Director, Geron
Imetelstat is a novel oligonucleotide and a potent inhibitor of telomerase. Preclinical studies suggest that imetelstat may play a key role in the inhibition of cancer stem cells. Phase II clinical trials are ongoing.
9:30 A Review of Stemline Therapeutic’s Clinical Programs
Eric Rowinsky, M.D., CMO & Head, Research & Development, Stemline Therapeutics, Inc.
10:00 Networking Coffee Break with Poster Viewing
10:30 Cancer Stem Cell Therapeutics from a Different Perspective: A Bottom-Up View
Norman J. Maitland, Ph.D., Director, Yorkshire Cancer Research Unit and Department of Biology, University of York, UK
There is currently no long-term treatment for prostate cancer once the tumor has escaped from the prostate and failed hormone treatment. Employing a biology-driven strategy, Pro-Cure Therapeutics has validated novel therapeutic targets, designed to target therapy resistant disease, in proprietary prostate cancer stem cell assays.
10:50 Elimination of Cancer Stem Cells by using Redirected T Cells
Patrick A. Baeuerle, Ph.D., Professor of Immunology, CSO & Senior Vice President, Micromet, Inc.
Cancer stem cells (CSC) appear resistant to anti-proliferative therapies. Temporarily non-dividing CSC can however be eliminated by T cells redirected with the help of bispecific antibodies that are simultaneously binding to a surface target on CSC, and to T cells.
11:10 Immunologic Strategies to Target Cancer Stem Cells
John S. Yu, M.D., Professor & Vice Chairman, Neurosurgery, Cedars-Sinai Medical Center; Chairman & CSO, ImmunoCellular Therapeutics
Recent observations of the laboratory have demonstrated that cancer stem cells are chemoresistant and may be the major reason for the recurrence of these deadly tumors. Hence we have developed novel immunologic strategies to target cancer stem cells.
11:30 Therapeutic Antibodies Targeting Colon Cancer Stem Cells
Christopher Reyes, Ph.D., CSO, Eclipse Therapeutics, Inc.
Eclipse Therapeutics is dedicated to the discovery and development of therapeutics that target cancer stem cells. This presentation will discuss Eclipse's cancer stem cell therapeutic antibody program and provide insights on the development of effective, functional antibodies targeting cancer stem cells.
11:50 Q&A with Emerging Therapeutic Programs
12:00 pm Close of Symposium
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